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Evidence Evidence that CFS/ME patients are low in methylation cycle metabolites: B vitamin evidence In a small study of 58 chronic fatigue syndrome patients with a history of Epstein-Barr infection and B-cell immunodeficiency, 81% responded to folinic acid

Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B 12 status compared with pregnant women of European ethnicity

There is a need to confirm the above-mentioned research results, as well as to thoroughly investigate the role of angiostatin in neurodegeneration, especially in preventing the development of these processes

Theoretical (mechanistic): the HGF/c-Met pathway governs growth, proliferation, and angiogenesis and is dysregulated in some cancers, so chronic potentiation raises a theoretical oncological concern

Mass spec confirmed the correct sequence without ambiguity

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